Fetal myocardial hypertrophy in an experimental model of gestational diabetes

@article{Menezes2001FetalMH,
  title={Fetal myocardial hypertrophy in an experimental model of gestational diabetes},
  author={H. Menezes and M. Barra and A. Bell{\'o} and C. B. Martins and P. Zielinsky},
  journal={Cardiology in the Young},
  year={2001},
  volume={11},
  pages={609 - 613}
}
Introduction: The frequent occurrence of prenatal hypertrophy of the muscular ventricular septum has been widely reported in fetuses of diabetic mothers. Objectives: This experimental study was carried out to test the hypothesis that the weight of the heart, the ratio of the cardiac weight to that of the body, the thickness of the muscular ventricular septum, and the myocytic profile within the ventricular septum are all increased in fetuses of diabetic rats in comparison to fetuses of normal… Expand
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DUCTUS VENOSUS FLOW, DIASTOLIC DYSFUNCTION AND MYOCARDIAL HYPERTROPHY IN FETUSES OF DIABETIC MOTHERS
Infants of diabetic mothers have an established risk of developing myocardial hypertrophy even with adequate maternal metabolic control. The pulsatility index of ductus venosus flow may be a usefulExpand
Assessment of diastolic ventricular function in fetuses of diabetic mothers using tissue Doppler
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Pulsed tissue Doppler shows evidence of impaired diastolic function, independently of the presence of myocardial hypertrophy in fetuses of diabetic mothers, in comparison tofetuses of nondiabetic mothers. Expand
Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model.
TLDR
In fetuses of hyperglycemic dams, expression of key genes that control and regulate cardiomyocyte electrophysiological properties, contractility, and metabolism are altered and may lead to major functional and clinical implications on the fetal heart. Expand
Changes in miR 21 and 23b expression in postnatal hypertrophic heart derived from gestational diabetes precede dilated cardiomyopathy.
TLDR
The temporal continuity of the study demonstrated a thinning of the ventricular wall, similar to dilated cardiomyopathy (DCM), which is the result of an active extracellular remodeling in the hearts of rat pups with GD. Expand
Molecular characterisation of neonatal cardiac hypertrophy and its regression
TLDR
Expression of 5 cardiac genes in the neonatal cardiac hypertrophy was characterised in both hypertrophic and regressive phases, providing a unique model for the testing of new drugs or genetic modifying factors in cardiachypertrophy. Expand
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TLDR
A prenatal IVS thickness of ≥4.5 mm or an IVS/LMWT ratio of ≤1.18 seems to be predictive of HCM and is associated with almost twofold higher risk of intrauterine fetal death and almost threefold higherrisk of possibly relevant perinatal mortality. Expand
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