Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention.

  title={Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention.},
  author={N. Scott Adzick},
  journal={Seminars in fetal & neonatal medicine},
  volume={15 1},
Myelomeningocele (MMC) is a common birth defect that is associated with significant lifelong morbidity. Little progress has been made in the postnatal surgical management of the child with spina bifida. Postnatal surgery is aimed at covering the exposed spinal cord, preventing infection, and treating hydrocephalus with a ventricular shunt. In-utero repair of open spina bifida is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying… CONTINUE READING
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