Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.

@article{Gerschenson2000FetalMH,
  title={Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.},
  author={Mariana Gerschenson and Stefanie Erhart and Catherine Paik and Marisa C St Claire and Kunio Nagashima and B Skopets and Steven W. Harbaugh and Jeffrey W. Harbaugh and William Wiles Gang Quan and Miriam C. Poirier},
  journal={AIDS research and human retroviruses},
  year={2000},
  volume={16 7},
  pages={635-44}
}
3'-azido-3'-deoxythymidine (AZT) is given to pregnant women positive for the human immunodeficiency virus type 1 (HIV-1) to reduce maternal-fetal viral transmission. To explore fetal mitochondrial consequences of this exposure, pregnant Erythrocebus patas monkeys were given daily doses of 1.5 mg (21% of the human daily dose) and 6.0 mg (86% of the human daily dose) of AZT/kg body weight (bw), for the second half of gestation. At term, electron microscopy of fetal cardiac and skeletal muscle… CONTINUE READING

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