Fetal ductal constriction caused by maternal ingestion of green tea in late pregnancy: an experimental study

@article{Zielinsky2012FetalDC,
  title={Fetal ductal constriction caused by maternal ingestion of green tea in late pregnancy: an experimental study},
  author={P. Zielinsky and J. Manica and A. Piccoli and L. H. Nicoloso and M. Barra and M. Alievi and I. Vian and A. Z{\'i}lio and P. Pizzato and J. Silva and L. Bender and M. Pizzato and H. Menezes and S. Garcia},
  journal={Prenatal Diagnosis},
  year={2012},
  volume={32}
}
The aim of this study was to test the hypothesis that experimental maternal intake of green tea in late pregnancy causes fetal ductus arteriosus constriction, probably because of prostaglandin inhibition. 
Increase of prostaglandin E2 in the reversal of fetal ductal constriction after polyphenol restriction
  • I. Vian, P. Zielinsky, +14 authors M. Markoski
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2018
TLDR
This study aimed to test the hypothesis that reversal of fetal ductal constriction after maternal restriction of polyphenol‐rich foods, in the third trimester of pregnancy, is accompanied by increased plasma levels of prostaglandin E2 (PGE2). Expand
Maternal ingestion of cocoa causes constriction of fetal ductus arteriosus in rats
TLDR
Supporting evidences are shown that there is a cause and effect relationship between maternal consumption of cocoa and fetal ductus arteriosus constriction and dietary guidance in late pregnancy to avoid high chocolate intake, to prevent fetal ductal constriction is shown. Expand
Restriction of Polyphenols and Fetal Ductal Flow in Normal Pregnancies : An Open Clinical Trial
Methods: Open clinical trial with 46 fetuses with gestational age (GA) ≥ 28 weeks submitted to 2 Doppler echocardiographic studies with an interval of at least 2 weeks, being the examiners blinded toExpand
Deleterious effects of maternal ingestion of cocoa upon fetal ductus arteriosus in late pregnancy
TLDR
It is hypothesized that this same mechanism is responsible for the harmful effect of polyphenol-rich foods, such as cocoa, upon the fetal DA after maternal intake of such substances in the third trimester of pregnancy, thereby rising the perspective of a note of caution for pregnant women diet. Expand
Nitric oxide and reactive species are modulated in the polyphenol‐induced ductus arteriosus constriction in pregnant sheep
TLDR
Pregnant sheep were submitted to oral PRF intake for 14 days to understand how this process occurs andfetal Doppler echocardiography, oxidative and inflammatory biomarkers and total polyphenol excretion were evaluated. Expand
Constriction of Fetal Ductus Arteriosus and Maternal Intake of Polyphenol-Rich Foods
TLDR
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INCREASE OF PROSTAGLANDIN E 2 IN THE REVERSAL OF DUCTAL CONSTRICTION AFTER POLYPHENOL RESTRICTION Short title : PGE 2 and Constriction Classification : Obstetrics
Objective: Anti-inflammatory substances that inhibit the synthesis of prostaglandins, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and polyphenol-rich foods, can cause constriction of theExpand
Improvement in fetal pulmonary hypertension and maturity after reversal of ductal constriction: prospective cohort study
  • P. Zielinsky, G. A. Magalhães, +7 authors I. Vian
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2021
TLDR
Resolution of fetal ductal constriction is followed by fall in the estimated mean pulmonary artery pressure and by increase in pulmonary vascular maturity, in a significant higher degree than the observed in normal fetuses in the same gestational age evolution period. Expand
Prenatal Effects of Maternal Consumption of Polyphenol-Rich Foods in Late Pregnancy upon Fetal Ductus Arteriosus
TLDR
New observations and findings are presented that may influence dietary orientation during pregnancy, especially of polyphenols, when ingested during the third trimester of pregnancy, which may influence the dynamics of fetal ductus arteriosus flow. Expand
Maternal Restriction of Polyphenols and Fetal Ductal Dynamics in Normal Pregnancy: An Open Clinical Trial
TLDR
The oriented restriction of third trimester maternal ingestion of polyphenol-rich foods for a period of 2 weeks or more improve fetal ductus arteriosus flow dynamics and right ventricular dimensions. Expand
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Reduction of maternal PRF intake during pregnancy, especially in the third trimester, is followed by complete reversal of DC (wide open DA), which may influence maternal dietary habits in late pregnancy. Expand
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Salicylamides, and six out of eight basic NSAID did not constrict the fetal ductus arteriosus, and further clinical implications of these results are discussed. Expand
Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
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The modifications in sonographic parameters and the other known risk factors may suggest a need for monitoring and intervention during antenatal period, and differences were founded in mean diastolic velocity and mean diASTolic velocity between the groups, both values are in the normal range. Expand
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A dramatic yet reversible increase in the incidence of indomethacin-induced ductal constriction occurs at 31 weeks' gestation, however, ductalconstriction can occur at any gestational age. Expand
Characteristic Morphology of the Constricted Fetal Ductus Arteriosus following Maternal Administration of Indomethacin
TLDR
Shortening of the ductal length was associated with both intrauterine constriction by indomethacin in experimental rats and neonatal physiologic constriction of control rats, but significantly greater shortening was seen with intrauterne constriction. Expand
Increased constriction of the ductus arteriosus by dexamethasone, indomethacin, and rofecoxib in fetal rats.
TLDR
Combined therapy may be an option in the medical management of PDA in premature infants before considering surgical treatment. Expand
OP18.03: Experimental study of the role of maternal consumption of green tea, mate tea and grape juice on fetal ductal constriction
TLDR
Radio-frequency (RF) seems to be an adequate method for ablation of retained trophoblast or placenta, with an optimal control of tissue destruction, in pregnant ewes. Expand
Nonsteroidal Antiinflammatory Drugs During Third Trimester and the Risk of Premature Closure of the Ductus Arteriosus: A Meta-Analysis
TLDR
Short-term use of NSAIDs in late pregnancy is associated with a significant increase in the risk of premature ductal closure, particularly in women exposed to indomethacin. Expand
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Ductal flow velocities are higher and right ventricular to left ventricular dimension ratios are larger in fetuses exposed to maternal ingestion of polyphenol-rich substances than in those not exposed. Expand
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OBJECTIVE To describe the relative incidence, presentation, and evolvement of fetuses with early ductus constriction. METHODS Twenty fetal echocardiograms indicating ductus constriction wereExpand
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