Fetal drug metabolism and its possible clinical implications.

  title={Fetal drug metabolism and its possible clinical implications.},
  author={B Krauer and Pierre Dayer},
  journal={Clinical pharmacokinetics},
  volume={21 1},
The ability of the human conceptus to metabolise xenobiotics during early gestation is now well established. Specific activities of liver enzymes have been demonstrated to exist in the late embryonic phase for numerous cytochrome P450 monooxygenases and many phase II enzymes such as glutathione-, N-acetyl-, sulpho- and uridine diphosphate-glucuronosyltransferase. As in the adult, fetal drug metabolism may function in a dual manner, either as a protective mechanism against chemical aggression… CONTINUE READING

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