Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.

@article{Keogh2007FetalderivedTU,
  title={Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.},
  author={Rosemary J. Keogh and Lynda K Harris and Abigail Freeman and Philip N. Baker and John D Aplin and Guy Stj Whitley and Judith E. Cartwright},
  journal={Circulation research},
  year={2007},
  volume={100 6},
  pages={834-41}
}
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss of endothelial and smooth muscle cells (SMC) is evident in remodeled arteries but the mechanisms underlying this transformation remain unknown. This study investigated the hypothesis that fetal trophoblast invading from the placenta instigate… CONTINUE READING
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