Fetal concentrations of the growth factors TGF-α and TGF-β1 in relation to normal and restricted fetal growth at term.

@article{Briana2012FetalCO,
  title={Fetal concentrations of the growth factors TGF-α and TGF-β1 in relation to normal and restricted fetal growth at term.},
  author={Despina D Briana and Sofia Liosi and Dimitrios Gourgiotis and Maria Boutsikou and Antonios S Marmarinos and Stavroula Baka and Dimitrios K. Hassiakos and Ariadne Malamitsi-Puchner},
  journal={Cytokine},
  year={2012},
  volume={60 1},
  pages={
          157-61
        }
}
Transforming growth factor-α (TGF-α) and TGF-β1 are major anti-inflammatory cytokines and substantially contribute to normal pregnancy outcome. TGF-α stimulates placental mitosis, whereas TGF-β1 is a critical regulator of trophoblast invasion and fetal growth. We aimed to study cord blood TGF-α and TGF-β1 concentrations in intrauterine-growth-restricted (IUGR, usually associated with abnormal trophoblast invasion, uteroplacental vascular insufficiency and enhanced inflammation) and appropriate… CONTINUE READING
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