Fetal cerebral and peripheral circulatory responses to hypoxia after nitric oxide synthase inhibition.

@article{Harris2001FetalCA,
  title={Fetal cerebral and peripheral circulatory responses to hypoxia after nitric oxide synthase inhibition.},
  author={A. Harris and S. Helou and C. Gleason and R. Traystman and R. Koehler},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2001},
  volume={281 2},
  pages={
          R381-90
        }
}
  • A. Harris, S. Helou, +2 authors R. Koehler
  • Published 2001
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
The increase in cerebral blood flow (CBF) during hypoxia in fetal sheep at 0.6 gestation is less than the increase at 0.9 gestation when normalized for differences in baseline CBF and oxygen consumption. Nitric oxide (NO) synthase (NOS) catalytic activity increases threefold during this period of development. We tested the hypothesis that administration of the NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) decreases the CBF response to systemic hypoxia selectively at 0.9… Expand
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