Fetal cells participate over time in the response to specific types of murine maternal hepatic injury.

@article{Khosrotehrani2007FetalCP,
  title={Fetal cells participate over time in the response to specific types of murine maternal hepatic injury.},
  author={Kiarash Khosrotehrani and Ronald Romero Reyes and Kirby L. Johnson and Richard B. Freeman and Robert N. Salomon and Inga Peter and Helene Stroh and Sarah Gu{\'e}gan and Diana W. Bianchi},
  journal={Human reproduction},
  year={2007},
  volume={22 3},
  pages={654-61}
}
BACKGROUND In humans, fetal microchimeric cells transferred to maternal tissues during pregnancy can adopt a hepatocyte phenotype. Our objective was to determine whether fetal cells participate in the response to specific murine post-partum hepatic injuries. METHODS Wild-type female mice were bred to males transgenic for the enhanced green fluorescent protein (GFP) (n = 42). Following delivery, we created models of chemical or surgical injury with carbon tetrachloride (CCl(4)) injection or by… CONTINUE READING

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