Fetal cell microchimerism in papillary thyroid cancer: a possible role in tumor damage and tissue repair.

@article{Cirello2008FetalCM,
  title={Fetal cell microchimerism in papillary thyroid cancer: a possible role in tumor damage and tissue repair.},
  author={Valentina Cirello and Maria Paola Recalcati and Marina Muzza and Stefania Rossi and Michela Perrino and Leonardo Vicentini and Paolo Beck-Peccoz and Palma Finelli and Laura Fugazzola},
  journal={Cancer research},
  year={2008},
  volume={68 20},
  pages={8482-8}
}
Fetal cells enter the maternal circulation during pregnancy and can persist in the maternal blood or tissues for decades, creating a physiologic microchimerism. Because papillary thyroid cancer (PTC) is more frequent in women, the role of persisting fetal male cells in this tumor has been investigated. Tumor tissue specimens were obtained from 63 women with PTC who had a male pregnancy before the diagnosis. Male cells, identified by PCR amplification of a male-specific gene, the sex-determining… CONTINUE READING
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