Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation.

@article{Prabowo2013FetalBL,
  title={Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation.},
  author={Avanita S. Prabowo and Jasper J. Anink and Martin Lammens and Mark D. Nellist and Ans M. W. van den Ouweland and Homa Adle-Biassette and Harvey B. Sarnat and Laura Flores-Sarnat and Peter B. Crino and E. Aronica},
  journal={Brain pathology},
  year={2013},
  volume={23 1},
  pages={45-59}
}
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the TSC1 or TSC2 genes and characterized by developmental brain abnormalities. We defined the spectrum of brain abnormalities in fetal TSC brain ranging from 23 to 38 gestational weeks. We hypothesized (i) prenatal activation of the target-of-rapamycin complex 1 (TORC1) signaling pathway; and (ii) activation of inflammatory pathways in fetal brain lesions. Immunocytochemical analysis of cortical… CONTINUE READING