Fetal and neonatal alloimmune thrombocytopenia.

  title={Fetal and neonatal alloimmune thrombocytopenia.},
  author={Eline S A van den Akker and Dick Oepkes},
  journal={Best practice & research. Clinical obstetrics & gynaecology},
  volume={22 1},
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is one of the major causes of both severe thrombocytopenia and intracranial haemorrhage in fetuses and term neonates. The incidence of FNAIT is estimated to be one in 1000-2000 births. FNAIT is caused by maternal immunoglobulin G alloantibodies, which cross the placenta and are directed against human platelet antigens (HPA) on fetal platelets. In Caucasian individuals, the immunodominant antigen is HPA-1a, which is responsible for… CONTINUE READING


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Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention

Archivum Immunologiae et Therapiae Experimentalis • 2015
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