Fetal and neonatal NK1.1+ Ly-49- cells can distinguish between major histocompatibility complex class I(hi) and class I(lo) target cells: evidence for a Ly-49-independent negative signaling receptor.

@article{Sivakumar1997FetalAN,
  title={Fetal and neonatal NK1.1+ Ly-49- cells can distinguish between major histocompatibility complex class I(hi) and class I(lo) target cells: evidence for a Ly-49-independent negative signaling receptor.},
  author={Pallavur V. Sivakumar and Michael Bennett and Vinay Kumar},
  journal={European journal of immunology},
  year={1997},
  volume={27 12},
  pages={3100-4}
}
Natural killer (NK) cell function is regulated by both positive and negative signaling receptors. In adult splenic NK cells, negative signaling has been shown to be mediated by the Ly-49 family receptors. NK1.1- 2B4+ CD3- cells that are phenotypically and functionally similar to adult splenic NK cells can be derived from murine fetal liver and thymus. These… CONTINUE READING