Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity

  title={Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity},
  author={V. Moulin and B. Tam and G. Castilloux and F. Auger and M. O'Connor-McCourt and A. Philip and L. Germain},
  journal={Journal of Cellular Physiology},
  • V. Moulin, B. Tam, +4 authors L. Germain
  • Published 2001
  • Medicine, Biology
  • Journal of Cellular Physiology
  • One of the differences between fetal and adult skin healing is the unique ability of fetal wounds to heal without contracture and scar formation. Studies have shown that the ratio between the three isoforms of TGFβ is different in adult and fetal wounds. Thus, we analyzed the capacity of adult and fetal human skin fibroblasts to contract collagen gels after stimulation with TGFβ isoforms. In control medium, fetal fibroblasts had a contractile capacity similar to that of adult fibroblasts… CONTINUE READING
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