Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain

@article{Windrem2004FetalAA,
  title={Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain},
  author={M. Windrem and Marta Nunes and W. Rashbaum and Theodore H Schwartz and Robert A Goodman and G. McKhann and N. Roy and S. Goldman},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={93-97}
}
Both late-gestation and adult human forebrain contain large numbers of oligodendrocyte progenitor cells (OPCs). These cells may be identified by their A2B5+PSA-NCAM− phenotype (positive for the early oligodendrocyte marker A2B5 and negative for the polysialylated neural cell adhesion molecule). We used dual-color fluorescence-activated cell sorting (FACS) to extract OPCs from 21- to 23-week-old fetal human forebrain, and A2B5 selection to extract these cells from adult white matter. When… Expand
Human fetal oligodendrocyte progenitor cells from different gestational stages exhibit substantially different potential to myelinate.
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Distinctive properties of human adult brain-derived myelin progenitor cells.
Enrichment of rat oligodendrocyte progenitor cells by magnetic cell sorting
Fate determination of adult human glial progenitor cells.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity.
  • S. C. Zhang, B. Ge, I. Duncan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1999
Identification and characterization of neuronal precursors and their progeny from human fetal tissue
Transplanting oligodendrocyte progenitors into the adult CNS
...
1
2
3
...