Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys

@article{Martinot2018FetalNI,
  title={Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys},
  author={Amanda Jezek Martinot and Peter Abbink and Onur Afacan and Anna K. Prohl and Dan H Barouch},
  journal={Cell},
  year={2018},
  volume={173},
  pages={1111-1122.e10}
}
The development of interventions to prevent congenital Zika syndrome (CZS) has been limited by the lack of an established nonhuman primate model. Here we show that infection of female rhesus monkeys early in pregnancy with Zika virus (ZIKV) recapitulates many features of CZS in humans. We infected 9 pregnant monkeys with ZIKV, 6 early in pregnancy (weeks 6-7 of gestation) and 3 later in pregnancy (weeks 12-14 of gestation), and compared findings with uninfected controls. 100% (6 of 6) of… CONTINUE READING
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Pre-Clinical Pregnancy Models for Evaluating Zika Vaccines.

  • Tropical medicine and infectious disease
  • 2019
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