Fetal Microchimerism in the Maternal Mouse Brain: A Novel Population of Fetal Progenitor or Stem Cells Able to Cross the Blood–Brain Barrier?

@article{Tan2005FetalMI,
  title={Fetal Microchimerism in the Maternal Mouse Brain: A Novel Population of Fetal Progenitor or Stem Cells Able to Cross the Blood–Brain Barrier?},
  author={Xiao Wei Tan and Hong Liao and Li Sun and Masaru Okabe and Zhi‐cheng Xiao and Gavin Stewart Dawe},
  journal={STEM CELLS},
  year={2005},
  volume={23}
}
We investigated whether fetal cells can enter the maternal brain during pregnancy. Female wild‐type C57BL/6 mice were crossed with transgenic Green Mice ubiquitously expressing enhanced green fluorescent protein (EGFP). Green Mouse fetal cells were found in the maternal brain. Quantitative real‐time polymerase chain reaction (PCR) of genomic DNA for the EGFP gene showed that more fetal cells were present in the maternal brain 4 weeks postpartum than on the day of parturition. After an… 
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Fetal cell microchimerism develops through the migration of fetus-derived cells to the maternal organs early after implantation.
Fetal cell microchimerism in the maternal mouse spinal cord
TLDR
The results indicate that fetal cells migrate into the spinal cords of a maternal mouse during and/or after the gestational period, and the fetal cells may differentiate into neurons in the spinal cord.
Are there fetal stem cells in the maternal brain?☆
TLDR
Investigation of whether a baby's stem cells can enter the maternal brain during pregnancy indicated that fetal stem Cells can not cross the blood-brain barrier to enter the mother's brain.
Maternal neoangiogenesis during pregnancy partly derives from fetal endothelial progenitor cells
TLDR
It is implied that fetal endothelial progenitor cells are acquired by the mother and participate in maternal angiogenesis during pregnancy, using various techniques to find the presence of Fetal endothelial cells lining blood vessels in maternal sites of inflammation.
Role of Fetal Stem Cells in Maternal Tissue Regeneration
TLDR
The study suggests that the amount of fetal cells in maternal mice significantly increased if injuries occurred during pregnancy, and appears to respond to maternal injury signals and may play a role in maternal tissue regeneration during pregnancy.
Increased fetal cell microchimerism in high grade breast carcinomas occurring during pregnancy
TLDR
Fetal cells—expressing cytokeratin—are always present in murine breast carcinomas associated with gestation, and Interestingly, high‐grade tumors contain more fetal cells.
Fetal microchimerism and maternal health during and after pregnancy
TLDR
The pregnancy-acquired low-grade chimeric state of women could have far-reaching implications, influencing recovery after injury or surgery, ageing, graft survival after transplantation, survival after cancer as well as deciding the protective effect of pregnancy against diseases later in life.
Feto-maternal cell trafficking: a transfer of pregnancy associated progenitor cells.
TLDR
The possible origins of this cell population are discussed, the most recent data suggesting that these fetal microchimeric cells may participate in maternal tissue regeneration processes are reviewed, and the possibility for fetal progenitor cells persisting after pregnancy to home to maternal injured tissue and to adopt various phenotypes is reviewed.
Feto-maternal cell trafficking
TLDR
The possible origins of this cell population are discussed, the most recent data suggesting that these fetal microchimeric cells may participate in maternal tissue regeneration processes are reviewed, and the possibility for fetal progenitor cells persisting after pregnancy to home to maternal injured tissue and to adopt various phenotypes is reviewed.
Maternal background strain influences fetal-maternal trafficking more than maternal immune competence in mice.
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