Fetal DNA in skin of polymorphic eruptions of pregnancy

  title={Fetal DNA in skin of polymorphic eruptions of pregnancy},
  author={S{\'e}lim Aractingi and Nadia Berkane and Philippe Bertheau and Caroline Le Gou{\'e} and Jean B. Dausset and Serge Uzan and Edgardo Delfino Carosella},
  journal={The Lancet},

Fetomaternal cell trafficking: a new cause of disease?

  • D. Bianchi
  • Medicine, Biology
    American journal of medical genetics
  • 2000
Fetomaternal cell trafficking provides a potential explanation for the increased prevalence of autoimmune disorders in adult women following their childbearing years, and the realization that following pregnancy, a woman becomes a chimera.

Detection of maternal-fetal microchimerism in the inflammatory lesions of patients with Sjögren's syndrome

Maternal-fetal microchimerism was shown for the first time to exist in the salivary glands and lungs of female patients with Sjögren's syndrome in this study, and the presence of non-host cells in the inflammatory lesions but not in the peripheral blood suggests a possible role for maternal- Fetal micro chimerism in the pathogenesis of SS.

Specific dermatoses of pregnancy other than pemphigoid gestationis.

The epidemiology, pathogenesis, clinical features as well as management of AEP and PEP are reviewed in detail, while ICP, which cannot be considered a primarily skin disease but may be managed first by dermatologists, are reported.

Polymorphic Eruption of Pregnancy Presented with Targetoid Lesions: A Report of Two Cases

Targetoid lesions in PEP are an uncommon presentation, and the differential diagnosis of PEP along with other dermatoses should be considered, however, the prognosis for this type of P EP is not different from that for classic PEP.

A review of literature of polymorphic eruption of pregnancy

Polymorphic eruption of pregnancy (PEP), also known as pruritic urticarial papules and plaques of pregnancy [PUPPP], is the most common of all the specific dermatoses of pregnancy and its exact pathogenesis is still unknown.

Tissue microchimerism is increased during pregnancy: a human autopsy study.

It is demonstrated that during pregnancy, a boost of chimeric cells is observed in women, with a distribution across organs, that parallels findings in mouse models.

Intrathyroidal fetal microchimerism in pregnancy and postpartum.

Fetal cells of immune origin were shown to accumulate within the thyroid glands of mice with EAT during pregnancy and the early postpartum, indicating that the inflamed thyroid gland was capable of accumulating fetal cells, including T cells and dendritic cells.

Microchimerism of Fetal Origin in Ovarian Tissues from Women with Pelvic Endometriosis

Fetal microchimeric cells, possibly from feto-maternal cell trafficking were detected in ovarian tissues with endometriosis were obtained from women who had prior male pregnancies, and further study is necessary to understand the role of persistent fetal microchineric cells in the progression of endometRIosis.

Fetal cell microchimerism in tissue from multiple sites in women with systemic sclerosis.

The results of this study suggest that fetal cells migrate from the peripheral circulation into multiple organs in women with SSc and could play a role in disease pathogenesis and that they may preferentially sequester in the spleen.

Maternal and Fetal Microchimerism: Implications for Human Diseases

Observations led to the hypothesis that microchimerism and HLA genes of host and nonhost cells are involved in autoimmune disease.



Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis.

This finding suggests that fetal cells persisting in the maternal circulation or tissues could be involved in the pathogenesis of systemic sclerosis by initiating a graft-versus-host reaction.

Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.

The data demonstrate the continued maternal circulation of fetalCD34+ or CD34+CD38+ cells from a prior pregnancy, which may represent a human analogue of the microchimerism described in the mouse and may have significance in development of tolerance of the fetus.

Isolation of fetal DNA from nucleated erythrocytes in maternal blood.

It is demonstrated that it is possible to isolate fetal gene sequences from cells in maternal blood by using monoclonal antibody against the transferrin receptor to identify nucleated erythrocytes in the peripheral blood of pregnant women.

PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies.

The sixfold elevation of fetal cells observed in maternal blood when the fetus had trisomy 21 indicates that noninvasive cytogenetic diagnosis of trisomally normal fetuses should be feasible and feto-maternal transfusion of nucleated cells appears to be influenced by fetal karyotype.

Specific pruritic diseases of pregnancy : a prospective study of 3192 pregnant women

The results show that the incidence of herpes gestationis is higher than is usually reported in the literature and that pruritus gravidarum must be considered in the presence of itching occurring during pregnancy, with or without skin eruption.

Specific dermatoses of pregnancy. Toward a comprehensive view?

THE INFLAMMATORY dermatoses that occur during pregnancy have been reported under a variety of confusing terms, such as erythema multiforme of pregnancy,1 prurigo annularis,2 toxaemic rash of