Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

@article{Strachan2004FetalAC,
  title={Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.},
  author={Gordon D Strachan and Kathleen L. Morgan and Linda Otis and John Caltagarone and Aryn H Gittis and Robert Bowser and Kelly L Jordan-Sciutto},
  journal={Biochemistry},
  year={2004},
  volume={43 38},
  pages={12113-22}
}
The fetal Alz-50 reactive clone 1 (FAC1) protein exhibits altered expression and subcellular localization during neuronal development and neurodegenerative diseases such as Alzheimer's disease. Using the yeast two-hybrid screen, the human orthologue of Keap1 (hKeap1) was identified as a FAC1 interacting protein. Keap1 is an important regulator of the oxidative stress response pathway through its interaction with the Nrf family of transcription factors. An interaction between full-length FAC1… CONTINUE READING

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