Ferulic acid suppresses activation of hepatic stellate cells through ERK1/2 and Smad signaling pathways in vitro.

@article{Xu2015FerulicAS,
  title={Ferulic acid suppresses activation of hepatic stellate cells through ERK1/2 and Smad signaling pathways in vitro.},
  author={Tianjiao Xu and Zhi Min Pan and Miaoxian Dong and Chunlei Yu and Yingcai Niu},
  journal={Biochemical pharmacology},
  year={2015},
  volume={93 1},
  pages={49-58}
}
Hepatic stellate cells (HSCs) are the primary source of matrix components in hepatic fibrosis. Ferulic acid (FA) has antifibrotic potential in renal and cardiac disease. However, whether FA comprises inhibitive effects of HSCs activation remains to be clarified. This study aims at evaluating the hypothesis that FA inhibits extracellular matrix (ECM)-related gene expression by the interruption of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) or/and Smad signaling pathways in HSC-T6… CONTINUE READING