Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.

Abstract

STUDY HYPOTHESIS We hypothesize that fertility disorders in patients with aberrant expression of Cysteine-RIch Secretory Protein 2 (CRISP2) could be linked to the proposed functional role of this protein in fertilization. STUDY FINDING Our in vivo and in vitro observations reveal that Crisp2-knockout mice exhibit significant defects in fertility… (More)
DOI: 10.1093/molehr/gaw005

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