Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia: The ESCALE study (SFCE)

  title={Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia: The ESCALE study (SFCE)},
  author={J{\'e}r{\'e}mie Rudant and Alicia Amigou and Laurent Orsi and Thomas Althaus and Guy Leverger and Andr{\'e} Baruchel and Yves Bertrand and Brigitte Nelken and Genevi{\`e}ve Plat and Gerard Michel and Nicolas Sirvent and Pascal Chastagner and St{\'e}phane Ducassou and Xavier Rialland and Denis H{\'e}mon and Jacqueline Clavel},
  journal={Pediatric Blood \& Cancer},
This study investigated the relationships between childhood acute leukemia (AL) and selective maternal and birth characteristics, including congenital malformations and the use of fertility treatment, for which the literature remains scarce. 

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History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype.

Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history limited to ALL.

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