Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia: The ESCALE study (SFCE)

@article{Rudant2013FertilityTC,
  title={Fertility treatments, congenital malformations, fetal loss, and childhood acute leukemia: The ESCALE study (SFCE)},
  author={J{\'e}r{\'e}mie Rudant and Alicia Amigou and Laurent Orsi and Thomas Althaus and Guy Leverger and Andr{\'e} Baruchel and Yves Bertrand and Brigitte Nelken and Genevi{\`e}ve Plat and Gerard Michel and Nicolas Sirvent and Pascal Chastagner and St{\'e}phane Ducassou and Xavier Rialland and Denis H{\'e}mon and Jacqueline Clavel},
  journal={Pediatric Blood \& Cancer},
  year={2013},
  volume={60}
}
This study investigated the relationships between childhood acute leukemia (AL) and selective maternal and birth characteristics, including congenital malformations and the use of fertility treatment, for which the literature remains scarce. 

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Because of the erroneous application of multiple publications, the conclusions of the recent paper were not reliable and it is shown that coffee drinking during pregnancy was risk factor for childhood acute lymphoblastic leukemia.

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

TLDR
It is suggested that maternal histories of stillbirth and miscarriage may be more frequent among mothers of CL cases and that folic acid supplementation during preconception may reduce the risk of CL.

Fertility treatments and childhood acute leukemia

TLDR
This special report investigates the evidence of a possible association specifically between childhood AL and assisted reproductive technology, and offers an outlook for the direction of this important field in the future.

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TLDR
Investigating the potential involvement of fertility treatments and other conditions of becoming pregnant (infertility, getting pregnant on birth control, maternal history of fetal loss) and folic acid supplements in the etiology of childhood leukemia found CL was not associated with difficulty in becoming pregnant.

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TLDR
In conclusion, IVF increases the incidence of premature and high-risk newborn, whereas pre-implantation diagnostic techniques can be used to reduce the likelihood of transmission of genetic diseases.

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TLDR
The findings suggest that ART conception is associated with an increased risk for childhood cancers, and the increased risk cannot be attributed to preterm birth or low birth weight.

History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype.

TLDR
Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history limited to ALL.

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

TLDR
In this meta-analysis involving >50,000 children, noteworthy associations by indices of fetal loss, age at diagnosis, and leukemia type are found; namely, of stillbirth with ALL and miscarriage history with infant ALL.

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