Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial.

@article{Behringer2012FertilityAG,
  title={Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial.},
  author={Karolin Behringer and Indra Thielen and Horst Dr Mueller and Helen Goergen and Angelika Diana Eibl and Johannes Rosenbrock and Teresa Veronika Halbsguth and Dennis A. Eichenauer and Michael Fuchs and Katrin S. Reiners and Jorg H Renno and Katrin van der Ven and Marietta Kuehr and Michael von Wolff and Volker Dr. Diehl and Andreas Engert and Peter Borchmann},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2012},
  volume={23 7},
  pages={
          1818-25
        }
}
BACKGROUND In the HD14 trial, 2×BEACOPPescalated+2×ABVD (2+2) has improved the primary outcome. Compared with 4×ABVD, this benefit might be compromised by more infertility in women. Therefore, we analyzed gonadal function and fertility. PATIENTS AND METHODS Women≤45 years in ongoing remission at least 1 year after therapy were included. Hormone parameters, menopausal symptoms, measures to preserve fertility, menstrual cycle, pregnancies, and offspring were evaluated. RESULTS Three hundred… CONTINUE READING
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