Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization
@article{Evans2001FertilinA, title={Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization}, author={J. Evans}, journal={BioEssays}, year={2001}, volume={23} }
One of the most important cell–cell interactions is that of the sperm with the egg. This interaction, which begins with cell adhesion and culminates with membrane fusion, is mediated by multiple molecules on the gametes. One of the best‐characterized of these molecules is fertilin β, a ligand on mammalian sperm and one of the first ADAMs (A Disintegrin and A Metalloprotease domain) to be identified. Fertilin β (also known as ADAM2) participates in sperm–egg membrane binding, and it has long… CONTINUE READING
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References
SHOWING 1-10 OF 91 REFERENCES
Evidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM
- Biology, Medicine
- The Journal of cell biology
- 1999
- 97
- PDF
Characterization of fertilin beta-disintegrin binding specificity in sperm-egg adhesion.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 2000
- 23
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1999
- 205
- PDF
A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion
- Biology, Medicine
- The Journal of cell biology
- 1997
- 227
- PDF
RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction*
- Biology
- The Journal of Biological Chemistry
- 2000
- 199
- PDF
Characterisation and role of integrins during gametic interaction and egg activation.
- Chemistry, Medicine
- Zygote
- 1996
- 38
Identification of Key Functional Amino Acids of the Mouse Fertilin β (ADAM2) Disintegrin Loop for Cell-Cell Adhesion during Fertilization*
- Biology, Medicine
- The Journal of Biological Chemistry
- 2000
- 80
- PDF
Analysis of the role of egg integrins in sperm‐egg binding and fusion
- Biology, Medicine
- Molecular reproduction and development
- 2000
- 21
Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.
- Biology, Medicine
- Journal of cell science
- 2000
- 180