Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation.

@article{Yang1999FerroxidaseAO,
  title={Ferroxidase activity of ferritin: effects of pH, buffer and Fe(II) and Fe(III) concentrations on Fe(II) autoxidation and ferroxidation.},
  author={X F Yang and N. Dennis Chasteen},
  journal={The Biochemical journal},
  year={1999},
  volume={338 ( Pt 3)},
  pages={615-8}
}
It is widely accepted that iron deposition in the iron storage protein ferritin in vitro involves Fe(II) oxidation, and that ferritin facilitates this oxidation at a ferroxidase site on the protein. However, these views have recently been questioned, with the protein ferroxidase activity instead being attributed to autoxidation from the buffer alone. Ligand… CONTINUE READING