Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors.

@article{Jai2020FerrousIB,
  title={Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors.},
  author={Jelena Kora{\'c} Ja{\vc}i{\'c} and L. Nikoli{\'c} and D. M. Stankovi{\'c} and Milo{\vs} Opa{\vc}i{\'c} and Milena S. Dimitrijevi{\'c} and D. Savi{\'c} and Sanja R Grguric Sipka and I. Spasojevi{\'c} and J. B. Pristov},
  journal={Free radical biology & medicine},
  year={2020}
}
  • Jelena Korać Jačić, L. Nikolić, +6 authors J. B. Pristov
  • Published 2020
  • Chemistry, Medicine
  • Free radical biology & medicine
  • Upon release in response to stress, epinephrine (Epi) may interact with labile iron pool in human plasma with potentially important (patho)physiological consequences. We have shown that Epi and Fe3+ build stable 1:1 high-spin bidentate complex at physiological pH, and that Epi does not undergo degradation in the presence of iron. However, the interactions of Epi with the more soluble Fe2+, and the impact of iron on biological activity of Epi are still not known. Herein we showed that Epi and… CONTINUE READING

    References

    SHOWING 1-10 OF 39 REFERENCES
    Iron and redox cycling. Do's and don'ts.
    • 41
    Citrate and albumin facilitate transferrin iron loading in the presence of phosphate.
    • 4
    The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.
    • 6,690
    • PDF
    Non-transferrin-bound iron transporters.
    • M. Knutson
    • Chemistry, Medicine
    • Free radical biology & medicine
    • 2019
    • 33