Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity.

@article{Cui2016FerrousII,
  title={Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity.},
  author={Zhenwen Cui and Zhihong Zhong and Yong Yang and Baofeng Wang and Yuhao Sun and Qingfang Sun and Guo-Yuan Yang and Liuguan Bian},
  journal={Journal of biochemical and molecular toxicology},
  year={2016},
  volume={30 8},
  pages={396-403}
}
Free radical damage caused by ferrous iron is involved in the pathogenesis of secondary brain injury after intracerebral hemorrhage (ICH). NF-E2-related factor 2 (Nrf2), a major phase II gene regulator that binds to antioxidant response element, represents an important cellular cytoprotective mechanism against oxidative damage. We hypothesized that Nrf2 might protect astrocytes from damage by Fe(2+) . Therefore, we examined cytotoxicity in primary astrocytes induced by iron overload and… CONTINUE READING

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