Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Abstract

Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal… (More)
DOI: 10.1021/ja411006a

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@inproceedings{Skouta2014FerrostatinsIO, title={Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models}, author={Rachid Skouta and Scott J. Dixon and Jianlin Wang and Denise E. Dunn and Marina Orman and Kenichi Shimada and Paul B Rosenberg and Donald C. Lo and Joel M. Weinberg and Andreas Linkermann and Brent R. Stockwell}, booktitle={Journal of the American Chemical Society}, year={2014} }