Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

  title={Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease},
  author={Brent R. Stockwell and Jos{\'e} Pedro Friedmann Angeli and H{\"u}lya Bayir and Ashley I. Bush and Marcus Conrad and Scott J. Dixon and Simone Fulda and Sergio Gasc{\'o}n and Stavroula K. Hatzios and Valerian E Kagan and Kay Noel and Xuejun Jiang and Andreas Linkermann and Maureen E Murphy and Michael G Overholtzer and Atsushi Oyagi and Gabriela Carolina Pagnussat and Jason J. K. Park and Qitao Ran and Craig S. Rosenfeld and Konstantin V Salnikow and Daolin Tang and Frank M. Torti and Suzy V. Torti and Shinya Toyokuni and K A Woerpel and Donna D. Zhang},
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes… CONTINUE READING


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