Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation.

  title={Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation.},
  author={Zhaobao Yin and HaiYan Jiang and Eunsook Y Lee and Mingwei Ni and Keith M. Erikson and Dejan M Milatovic and Aaron B. Bowman and Michael Aschner},
  journal={Journal of neurochemistry},
  volume={112 5},
Although manganese (Mn) is an essential trace element for human development and growth, chronic exposure to excessive Mn levels can result in psychiatric and motor disturbances, referred to as manganism. However, there are no known mechanism(s) for efflux of excess Mn from mammalian cells. Here, we test the hypothesis that the cytoplasmic iron (Fe) exporter ferroportin (Fpn) may also function as a Mn exporter to attenuate Mn toxicity. Using an inducible human embryonic kidney (HEK293T) cell… CONTINUE READING
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