Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease.

@article{Song2010Ferroportin1B,
  title={Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease.},
  author={Ning Hong Song and Jun Wang and Hong Jiang and Jun-xia Xie},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 2},
  pages={332-41}
}
Iron-induced oxidative stress is thought to play a crucial role in the pathogenesis of Parkinson's disease (PD). Based on our previous in vivo experiments showing that down-regulation of the iron transporters ferroportin 1 (FP1) and hephaestin (HP) might account for the nigral iron accumulation in 6-hydroxydopamine (6-OHDA)-lesioned animal models, in this study we investigated whether FP1 and HP were involved in cellular iron accumulation and the underlying mechanisms in a cell model of PD. The… CONTINUE READING

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