Ferrocenes as potential anticancer drugs. Facts and hypotheses

  title={Ferrocenes as potential anticancer drugs. Facts and hypotheses},
  author={V. N. Babin and Yury A. Belousov and Vyacheslav I. Borisov and V. V. Gumenyuk and Yury S. Nekrasov and L. A. Ostrovskaya and Irina K. Sviridova and Nataliya S. Sergeeva and Alexander A. Simenel and Lubov V. Snegur},
  journal={Russian Chemical Bulletin},
We analyzed the research data on antitumor effects of a wide range of ferrocene compounds and discussed possible mechanisms of their bioactivities. Current trends in the study of anticancer effects of ferrocene derivatives were considered. Promising ways in the design of low-toxicity anticancer ferrocene-based drugs of new generation were outlined. 

Anticancer Effect of an Electronically Coupled Oligoferrocene

The mode of anticancer activity of simple ferrocenes often relies on their intracellular oxidation with the formation of cytotoxic ferrocenium species. The former compounds should be considered as ...

Antileukemic, Antioxidant, Anti-Inflammatory and Healing Activities Induced by a Polyphenol-Enriched Fraction Extracted from Leaves of Myrtus communis L.

The polyphenol-enriched fraction extracted from Myrtus communis has a pharmacological potential as both preventive and therapeutic agent and the activities found at the dose of 100 mg/kg were better than those observed using a reference drug.

Synthesis of Ferrocene-Oxadiazole Complexes and a Determination of Their LogD Values

During the drug design process, there are many different approaches that researchers can take to improve the overall efficacy of a potential drug candidate. Aside from attempting to understand how

Azinyl derivatives of ferrocene and cymantrene. Synthesis and properties

In the present review comparative data concerning various synthetic approaches and methodologies used in the series of ferrocene and cymantrene derivatives to create various materials, namely,

Polyacrylates of Metals Are a New Class of the Potential Antitumor Drugs

The results of preclinical study of the original antitumor drug aurumacryl (gold polyacrylate), which belongs to polyacrylates of metals (PAMs), a new class of compounds for use in oncology, are


The pre-clinical study of the original antitumor drug aurum polyacrylate (aurumacryl) which belongs to such new for oncology group of compounds as polyacRYlates of metals seems rather promising.

Experimental study of the antitumor effect of aurumacryl

Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation of cells in the proliferative resting phase G0 and a substantial decrease in the percentage of proliferating cells.

Ferrocene derivatives: Potential anticancer material

Asifa Nigar, Naveed Kausar janjua, Asghari Gul, Abid Ali, Zareen Akhter*, Sadia Mehmood Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan. Department of Chemistry, Park Road



Antitumor activities of ferrocene compounds

Data on the antitumor activities of ferrocene compounds and the results concerning the mechanisms of their action published between 1995 and 2010 are discussed. The biomedical aspects of the study of

Application of ferrocene and its derivatives in cancer research

The use of ferrocene-based compounds for medicinal applications is an active research area. Many reports have demonstrated that some ferrocenyl derivatives are highly active against several diseases,

Ferrocene modification of organic compounds for medicinal applications

The results of the authors on the synthesis of ferrocene-containing organic compounds obtained in 1998–2013 are summarized. The review is focused on the ferrocene modifications of purine and

Synthesis of novel ferrocenyl sugars and their antimalarial activities.

Synthesis of potential antineoplastic agents. XXII. Compounds related to 1-nitro-3-((p-phenylbenzylidene)amino)guanidine.

  • F. Popp
  • Chemistry
    Journal of pharmaceutical sciences
  • 1973
The nitroguanylhydrazone of 4-biphenylcarboxaldehyde exhibits antineoplastic activity in the Walker 256 and KB test systems. Other nitroguanylhydrazones and other derivatives of

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine

ABSTRACT The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible,