Ferrocene tripeptide Gly-Pro-Arg conjugates: synthesis and inhibitory effects on Alzheimer's Aβ(1-42) fibrillogenesis and Aβ-induced cytotoxicity in vitro.

@article{Zhou2013FerroceneTG,
  title={Ferrocene tripeptide Gly-Pro-Arg conjugates: synthesis and inhibitory effects on Alzheimer's Aβ(1-42) fibrillogenesis and Aβ-induced cytotoxicity in vitro.},
  author={Binbin Zhou and Chun-lan Li and Yuan-Qiang Hao and Muya Chabu Johnny and You-Nian Liu and Juan Li},
  journal={Bioorganic & medicinal chemistry},
  year={2013},
  volume={21 2},
  pages={395-402}
}
Alzheimer's disease (AD) is the most common cause of dementia, and currently there is no clinical treatment to cure it or to halt its progression. Aggregation and fibril formation of β-amyloid peptides (Aβ) are central events in the pathogenesis of AD. Many efforts have been spent on the development of effective inhibitors to prevent Aβ fibrillogenesis and… CONTINUE READING