Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

@article{Alkhateeb2012FerritinSB,
  title={Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages},
  author={Ahmed A. Alkhateeb and Bing Han and James R. Connor},
  journal={Breast Cancer Research and Treatment},
  year={2012},
  volume={137},
  pages={733-744}
}
Tumor-associated macrophages play a critical role in breast tumor progression; however, it is still unclear what effector molecular mechanisms they employ to impact tumorigenesis. Ferritin is the primary intracellular iron storage protein and is also abundant in circulation. In breast cancer patients, ferritin is detected at higher levels in both serum and tumor lysates, and its increase correlates with poor clinical outcome. In this study, we comprehensively examined the distribution of… CONTINUE READING