Ferritin mRNAs on rat liver membrane-bound polysomes synthesize ferritin that does not translocate across membranes.

@article{Tacchini1992FerritinMO,
  title={Ferritin mRNAs on rat liver membrane-bound polysomes synthesize ferritin that does not translocate across membranes.},
  author={Lorenza Tacchini and Emilia Rappocciolo and Mercedes Ferrero and Luisa Schiaffonati and Gaetano Cairo},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1131 2},
  pages={133-8}
}
Ferritin is a typical intracellular protein but small amounts are also present in serum and other biological fluids. The source and physiological significance of serum ferritin are still obscure. The presence of ferritin mRNAs on polysomes bound to endoplasmic reticulum (ER) could be relevant for the secretion of ferritin. By Northern blot analysis we found significant amounts of both L and H subunit mRNAs on rat liver membrane-bound polysomes. Immunoprecipitation of translational products of… CONTINUE READING

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