Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions.

@article{Harrell1991FerritinMI,
  title={Ferritin mRNA: interactions of iron regulatory element with translational regulator protein P-90 and the effect on base-paired flanking regions.},
  author={Charles Harrell and A. R. McKenzie and Maria M. Patino and William E. Walden and Elizabeth C. Theil},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 10},
  pages={4166-70}
}
The ferritin iron regulatory element (IRE), a conserved sequence of 28 nucleotides in a hairpin loop, is a conserved mRNA-specific translational regulatory element; flanking the IRE are regions of varying sequence, which form 9-17 base pairs close to the 5' cap. P-90 is a ferritin mRNA-specific translation regulatory protein purified from animal liver and reticulocytes. To study the P-90-RNA interaction, protein nucleases (RNase S1 and T1) and chemical nucleases FeEDTA and/or 1,10… CONTINUE READING

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