Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition.

@article{Zhang2009FerritinHC,
  title={Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition.},
  author={Ke-hua Zhang and Hong-yu Tian and Xia Gao and Wei-wei Lei and Ying Hu and Dongmei Wang and Xin-chao Pan and Mei-lan Yu and Gen-jun Xu and Fu-kun Zhao and J Song},
  journal={Cancer research},
  year={2009},
  volume={69 13},
  pages={5340-8}
}
The epithelial-mesenchymal transition (EMT) plays a critical role in tumor progression. To obtain a broad view of the molecules involved in EMT, we carried out a comparative proteomic analysis of transforming growth factor-beta1 (TGF-beta1)-induced EMT in AML-12 murine hepatocytes. A total of 36 proteins with significant alterations in abundance were identified. Among these proteins, ferritin heavy chain (FHC), a cellular iron storage protein, was characterized as a novel modulator in TGF-beta1… CONTINUE READING

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Ubiquitin conjugation is not required for the degradation and elevation of labile iron pool

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