Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.

@article{Ruddell2009FerritinFA,
  title={Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.},
  author={Richard G Ruddell and Diem Hoang-Le and Joanne M. Barwood and Paul S Rutherford and Terrance J Piva and Dianne J Watters and Paolo Santambrogio and Paolo Arosio and Grant A Ramm},
  journal={Hepatology},
  year={2009},
  volume={49 3},
  pages={887-900}
}
UNLABELLED Circulating ferritin levels reflect body iron stores and are elevated with inflammation in chronic liver injury. H-ferritin exhibits a number of extrahepatic immunomodulatory properties, although its role in hepatic inflammation and fibrogenesis is unknown. Hepatic stellate cells respond to liver injury through production of proinflammatory mediators that drive fibrogenesis. A specific receptor for ferritin has been demonstrated on activated hepatic stellate cells, although its… CONTINUE READING