Ferritin-dependent lipid peroxidation by stimulated neutrophils: inhibition by myeloperoxidase-derived hypochlorous acid but not by endogenous lactoferrin.

Abstract

Human neutrophils stimulated with phorbol myristate acetate or formylmethionylleucylphenylalanine caused superoxide-dependent release of iron from feritin, measured as the formation of a ferrous-ferrozine complex. The stimulated cells also caused ferritin-dependent peroxidation of phospholipid liposomes. Peroxidation was inhibited by lactoferrin, but only… (More)

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