Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

@article{Pham2004FerritinHC,
  title={Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species},
  author={Can G. Pham and Concetta Bubici and Francesca Zazzeroni and Salvatore Papa and Joy Jones and Kellean Alvarez and Shanthi Jayawardena and Enrico De Smaele and Rong Cong and Carole Beaumont and Frank M. Torti and Suzy V. Torti and Guido Franzoso},
  journal={Cell},
  year={2004},
  volume={119},
  pages={529-542}
}
al., 2002). Cytotoxicity caused by ROS is mediated in part by the JNK pathway (Matsuzawa et al., 2002). Acti-During inflammation, NF-␬B transcription factors an-vation of this pathway by TNF␣ promotes death by in-tagonize apoptosis induced by tumor necrosis factor ducing cleavage of the Bcl-2 family BH3-only protein, (TNF)␣. This antiapoptotic activity of NF-␬B involves Bid, into jBid, which targets mitochondria to trigger re-suppressing the accumulation of reactive oxygen spe-lease of Smac… CONTINUE READING

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