Ferritin H induction by histone deacetylase inhibitors.

  title={Ferritin H induction by histone deacetylase inhibitors.},
  author={Wei Wang and Xiumin Di and Suzy V. Torti and Frank M. Torti},
  journal={Biochemical pharmacology},
  volume={80 3},
Because both iron deficiency and iron excess are deleterious to normal cell function, the intracellular level of iron must be tightly controlled. Ferritin, an iron binding protein, regulates iron balance by storing iron in a bioavailable but nontoxic form. Ferritin protein comprises two subunits: ferritin H, which contains ferroxidase activity, and ferritin L. Here we demonstrate that ferritin H mRNA and protein are induced by histone deacetylase inhibitors (HDAC inhibitors), a promising class… CONTINUE READING


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