Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus.

@article{Herlocher2001FerretsAA,
  title={Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus.},
  author={M Louise Herlocher and Stephanie Elias and Rachel K Truscon and Sarah Harrison and David P. Mindell and Cara Simon and Arnold S. Monto},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={184 5},
  pages={542-6}
}
Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome. Ferrets were infected initially with A/Sydney/5/97 (H3N2) or A/LA/1/87 (H3N2) intranasally, and transmission chains were established by housing infected ferrets with noninfected ferrets with no influenza antibody titer against the infecting virus. Ferrets infected with A/Sydney were seronegative for A/Sydney and… CONTINUE READING

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