Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.

@article{Kaewpiboon2014FeroniellinAA,
  title={Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.},
  author={Chutima Kaewpiboon and Serm Surapinit and Waraporn Malilas and Jeong Moon and Preecha Phuwapraisirisan and Santi Tip-pyang and Randal N Johnston and Sang Seok Koh and Wanchai Assavalapsakul and Y K Chung},
  journal={International journal of oncology},
  year={2014},
  volume={44 4},
  pages={1233-42}
}
During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time-dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription… CONTINUE READING

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