Fermenting next generation glycosylated therapeutics.

  • Xi Chen
  • Published 2011 in ACS chemical biology


Mutants of glycosyltransferases and related sugar nucleotide biosynthetic enzymes have been essential for in vitro glycorandomization to create libraries of novel glycosylated natural products and derivatives. These diverse glycorandomized compounds can now be produced in vivo economically by fermenting engineered Escherichia coli cells that express enzyme mutants.

DOI: 10.1021/cb100375y
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@article{Chen2011FermentingNG, title={Fermenting next generation glycosylated therapeutics.}, author={Xi Chen}, journal={ACS chemical biology}, year={2011}, volume={6 1}, pages={14-7} }