Fermentation optimization for the production of lovastatin by Aspergillus terreus : use of response surface methodology

@inproceedings{Lpez2004FermentationOF,
  title={Fermentation optimization for the production of lovastatin by Aspergillus terreus : use of response surface methodology},
  author={J C L{\'o}pez and J. R. Sanchez Perez and J. M. Fern{\'a}ndez Sevilla and F A Fernandez and Emilio Molina Grima and Yusuf Chisti},
  year={2004}
}
A Box–Behnken experimental design was used to investigate the effects of five factors—ie oxygen content in the gas phase; concentrations of C, N and P; and fermentation time—on the concentrations of biomass and lovastatin produced in batch cultures of Aspergillus terreus. The values of the various factors in the experiment ranged widely, as follows: 20–80% (v/v) oxygen in the aeration gas; 8–48 g dm−3 C-concentration; 0.2–0.6 g dm−3 N-concentration; 0.5–2.5 g dm−3 phosphate-concentration; and 7… CONTINUE READING
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