• Corpus ID: 33517618

Fermentation , Isolation and Biological Activities

@inproceedings{Inoue2008FermentationI,
  title={Fermentation , Isolation and Biological Activities},
  author={Hiroyuki Inoue and Hiroyuki Kumagai and Michiyo Osono and Motoko MATSUFUJIa and Tomohiro SAMESHIMAa and Naoto KAWAMURAa and Tetsuya Someno and Masaaki Ishizuka and Tomio Takeuchi},
  year={2008}
}
Osteoclasts are large multinucleated cells that are induced from osteoclasts precursors and play a significant role for resorption of bone1-3). These cells are involved in pathogenic destruction of bone such as osteoporosis, Paget's disease, rheumatoid arthritis and humoral hyper calcemia of malignancy (HHM)4-7). Most of these diseases are thought to be due to an imbalance between bone resorption and formation. Because the inhibition of bone resorption is a primary therapeutic objective, we… 
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