• Corpus ID: 33517618

Fermentation , Isolation and Biological Activities

  title={Fermentation , Isolation and Biological Activities},
  author={Hiroyuki Inoue and Hiroyuki Kumagai and Michiyo Osono and Motoko MATSUFUJIa and Tomohiro SAMESHIMAa and Naoto KAWAMURAa and Tetsuya Someno and Masaaki Ishizuka and Tomio Takeuchi},
Osteoclasts are large multinucleated cells that are induced from osteoclasts precursors and play a significant role for resorption of bone1-3). These cells are involved in pathogenic destruction of bone such as osteoporosis, Paget's disease, rheumatoid arthritis and humoral hyper calcemia of malignancy (HHM)4-7). Most of these diseases are thought to be due to an imbalance between bone resorption and formation. Because the inhibition of bone resorption is a primary therapeutic objective, we… 
10 Citations
Madindoline A Affects the Osteogenic Potential and the Wnt Signaling Pathways during Osteogenic Differentiation of Human Mesenchymal Stem Cells in vitro
Signals are provided for the first time indications of an in vitro osteoinduction potential of the interleukin-6 (IL-6) inhibitor MadA and its relation to the bone-inducing Wnt signaling pathways.
Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo
The therapeutic potential of thiocoraline, which induced activation of the Notch pathway, in carcinoid tumors was demonstrated and, formulated with polymeric micelles, slowed carcinoid tumor progression.
Taxonomy, Physiology, and Natural Products of Actinobacteria
SUMMARY Actinobacteria are Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial
Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi
This review highlights the occurrence, structures and biological activities of the fungal CDPs reported until October 2017.
Understanding In-Silico Approaches to Design Synthetic Antifungal Peptides to Combat Fungal Infections like Mucormycosis
The present scenario of the disease, AMPs as antifungal therapy, role, classification of antif fungus peptides, mechanism of action, advantages and limitations of natural AMPs, important physicochemical properties taken into account while designing synthetic AMPs (SAMPs) and the workflow pipeline to characterize and predict potential syntheticAMPs are discussed.
Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms
  • K. Ranjan
  • Biology, Medicine
    Gastrointestinal Disorders
  • 2020
This review highlights the signaling cascades encrypted within ER and mitochondria in IECs and/or myeloid cells to dissipate chronic stress in maintaining intestinal homeostasis.
Screening for Genes Coding for Putative Antitumor Compounds, Antimicrobial and Enzymatic Activities from Haloalkalitolerant and Haloalkaliphilic Bacteria Strains of Algerian Sahara Soils
In addition to their haloalkali character, the presence of genes coding for putative antitumor compounds, combined with the antimicrobial activity against a broad range of indicator strains and their enzymatic potential makes them suitable for biotechnology applications.
HEx: A heterologous expression platform for the discovery of fungal natural products
The HEx platform for rapid discovery of natural products from any fungal species, even those that are uncultivable, and opens the door to discovery of the next generation of natural Products.
Streptomyces Pneumonia in an Immunocompromised Patient: A Case Report and a Review of Literature
This study focuses on Streptomyces infections in immunocompromised patients with cancer and investigates the role of chemotherapy in the development of these infections.
Screening Marine Fungi for Inhibitors of the C4 Plant Enzyme Pyruvate Phosphate Dikinase: Unguinol as a Potential Novel Herbicide Candidate
Results indicate that unguinol inhibits PPDK via a novel mechanism of action which also translates to an herbicidal effect on whole plants.


Advances in bone biology: the osteoclast.
Future research is needed to further delineate the signaling pathways involved in osteoclastic bone resorption in response to cytokines and hormones, as well as to identify the molecular events required for commitment of multipotent precursors to the osteoclast lineage.
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.
TRACP-positive multinucleated cells formed in response to osteotropic hormones in mouse marrow cultures satisfy most of the criteria of osteoclasts, and osteoblasts may play an important role in osteoclast formation.
Cellular biology of bone-resorbing cells.
  • N. Athanasou
  • Biology
    The Journal of bone and joint surgery. American volume
  • 1996
The origin and formation of osteoclasts will be considered, along with mechanisms governing their recruitment, activation, and function, and the manner in which these mechanisms contribute to osteoclastic bone resorption under various pathological conditions as well as the possible roles of other cells (both skeletal and extraskeletal in origin).
Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function
  • C. Minkin
  • Biology
    Calcified Tissue International
  • 2006
Tartrate-resistant acid phosphatases of bone may be suitable biochemical probes for osteoclast function, but it will be necessary to achieve further purification in order to develop analytical methods with sufficient sensitivity and specificity to ensure precise localization and quantitation.
1,25-Dihydroxyvitamin D3 causes formation of multinucleated cells with several osteoclast characteristics in cultures of primate marrow.
The data suggest that the multinucleated cells in the authors' culture have several characteristics of osteoclasts and that the potent bone-resorbing activity of 1,25-dihydroxyvitamin D3 in vivo and in vitro may be mediated in part by stimulation of marrow mononuclear cells to form osteoclast.
Parathyroid hormone (PTH)-related protein is a potent stimulator of osteoclast-like multinucleated cell formation to the same extent as PTH in mouse marrow cultures.
Results show that PTHrP is a potent stimulator of osteoclast-like MNC formation to almost the same extent as PTH and is most likely mediated through the same receptor.
Parathyroid hormone‐related protein and hypercalcemia
There appears to be little doubt that PTH‐rP is the major mediator of hypercalcemia in patients with HHM, although it is possible that other factors also could contribute in some patients.
Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation
Evidence is established by differential display polymerase chain reaction of mRNA that interleukin (IL)-18 is expressed by osteoblastic stromal cells and inhibits OCL formation via GM–CSF production and not via IFN-γ production.
ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp. F-1490. II. Structure determination and synthesis.
The structure of ICM0201 was determined to be (3S,10aR)-3, 4a-dihydroxy-2,3,4,4a-tetrahydro-2H-pyrano[3,2-b]benzo[e]morpholine-9-carboxylic acid by spectroscopic analyses and chemical studies.
PGE2 stimulates both resorption and formation of bone in vitro: Differential responses of the periosteum and the endosteum in fetal rat long bone cultures
The ability of PGE2 to stimulate bone resorption in vitro and in vivo is well established but the effects of this compound on bone formation are still controversial. Recent clinical reports have