Fermentation, isolation and characterization of antibiotic PR-1350.

@article{Andersen1983FermentationIA,
  title={Fermentation, isolation and characterization of antibiotic PR-1350.},
  author={Niels R Andersen and H O Lorck and P R Rasmussen},
  journal={The Journal of antibiotics},
  year={1983},
  volume={36 7},
  pages={753-60}
}
A number of strains of Oidiodendron truncatum was shown to produce a new antibiotic, PR-1350, which was isolated in the form of an amorphous powder either directly or via a crystalline monomethanolate, PR-1381, which in solution is reconverted to the parent compound. The antibiotic inhibits a broad spectrum of Gram-positive and Gram-negative bacteria in vitro, and has been shown to be active against P-388 lymphocytic leukemia in mice. Biosynthetic considerations based on the results of [1-13C… CONTINUE READING

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