Fermentation, isolation, characterization and structure of antibiotic U-58,431.

  title={Fermentation, isolation, characterization and structure of antibiotic U-58,431.},
  author={Libor Slechta and Constance G. Chidester and Fritz Reusser},
  journal={The Journal of antibiotics},
  volume={33 9},
A new antibiotic U-58,431 has been isolated from the fermentation broth of Streptomyces helicus DIETZ and LI, sp. n. (UC-5837) and the structure of this antibiotic, namely, 6-amino-3,4,5,8-tetrahydro-4,9-dihydroxy-3-methyl-5,8-dioxo-1,4-ethano-1H-2-benzopyron-7-carboxamide has been determined by X-ray crystallography. The antibiotic inhibits a variety of Gram-positive and Gram-negative bacteria in vitro. However, it is toxic to mice and does not protect experimentally infected animals when… Expand
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  • F. Reusser
  • Biology, Medicine
  • Advances in applied microbiology
  • 1963
The nature and function of various recombination mechanisms encountered in microorganisms are discussed and the structural aspects of DNA and RNA are described in moderate detail since both represent the chemical basis of the genetic material. Expand