Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.

@article{Pelletier2002Fep1AI,
  title={Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.},
  author={Benoit Pelletier and Jude Beaudoin and Y. Mukai and Simon Labb{\'e}},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 25},
  pages={22950-8}
}
Schizosaccharomyces pombe cells acquire iron under high affinity conditions through the action of a cell surface ferric reductase encoded by the frp1(+) gene and a two-component iron-transporting complex encoded by the fip1(+) and fio1(+) genes. When cells are grown in the presence of iron, transcription of all three genes is blocked. A conserved regulatory element, 5'-(A/T)GATAA-3', located upstream of the frp1(+), fip1(+), and fio1(+) genes, is necessary for iron repression. We have cloned a… CONTINUE READING
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