Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes.

  title={Fenugreek increases insulin-stimulated creatine content in L6C11 muscle myotubes.},
  author={Kristyen A Tomcik and William J. Smiles and Donny M Camera and Helmut Martin H{\"u}gel and John A. Hawley and Rani Watts},
  journal={European journal of nutrition},
  volume={56 3},
PURPOSE Creatine uptake by muscle cells is increased in the presence of insulin. Accordingly, compounds with insulin-like actions may also augment creatine uptake. The aim of this study was to investigate whether Trigonella foenum-graecum (fenugreek), an insulin mimetic, increases total intracellular creatine levels in vitro. METHODS Total cellular creatine content was measured fluorometrically in L6C11 muscle myotubes treated for 1, 4, and 24 h with 0.5 mM creatine (CR), CR and 20 μg/mL… CONTINUE READING
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